LILONGWE-(MaraviPost )-Malawi is currently grappling with a critical shortage of First-Line anti-Tuberculosis (TB) medications, particularly the essential combination therapy known as RHZE which includes Rifampicin, Isoniazid, Pyrazinamide, and Ethambutol due to a global supply chain disruption.
In a statement,Secretary for Health Samson Mndolo confirmed the nationwide shortage, attributing it to a global shortfall in World Health Organization (WHO) prequalified Active Pharmaceutical Ingredients (APIs), which are crucial for the production of anti-TB drugs.
“This global shortage is largely due to the sudden and temporary closure of one of the major WHO prequalified API producers,”
“This has significantly disrupted supply chains and delayed the delivery of essential shipments that were initially expected in March 2025.” said Mndolo.
He added that while the situation is alarming, the Ministry is working around the clock to minimize the impact and ensure continued access to TB care.
A new consignment of RHZE is expected to arrive by the end of August 2025, and the Ministry is actively engaging with procurement agents to expedite delivery potentially bringing the shipment in earlier than scheduled.
Despite the shortage, Mndolo reassured the public that some stocks remain available in health facilities nationwide. Current estimates suggest these will last for approximately two months, based on average national consumption rates.
The National TB and Leprosy Elimination Program (NTLEP) has voiced deep concern over the potential implications of the shortage. TB treatment requires uninterrupted medication over several months, and any disruption could lead to the development of drug-resistant strains and worsening patients outcomes.
“The Ministry of Health recognizes the critical importance ofe uninterrupted TB treatment,”
“Our Procurement and Supply Chain teams are actively identifying alternative suppliers and working to expedite incoming shipments to avoid further disruption.”Mndolo said.
In the meantime, the Ministry is advising all health facilities to Prioritize existing stock for patients already undergoing treatment,avoid new patients on RHZE unless adequate stock is confirmed
As TB remains one of Malawi’s most pressing public health concerns, the Ministry is urging both healthcare workers and the public to remain calm and cooperate with interim measures.
Authorities reiterated their commitment to ensuring access to quality TB care and restoring normal drug supply levels as quickly as possible.